HUMAN PAPILLOMA VIRUS INFECTION (VENEREAL WARTS) – CLINICAL MANIFESTATIONS
The warts have a variable morphology; they are flat and small resembling
skin warts on cooler dry areas of the body. On warm moist areas they are often large and filiform. Warts may be single or multiple. Cervical lesions are not warty. Anorectal and genital warts may undergo malignant change.
In females, the vulva, particularly at the introitus and on the labia, is
usually affected. The perineum, perianal region, vagina and cervix may also be involved. Subclinical HPV infection of the cervix is commonly detected by cervical cytology or colposcopy.
in males, warts are typically located on the prepuce and fraenum, around
the coronal sulcus or at the meatus. They are frequently located on the shaft and surrounding skin but are infrequently found on the scrotum or in the urethra. Particularly in homosexual men, they may be found in the perianal region, anus and rectum. Perianal warts can be numerous and large.
Rectal HPV infection may be associated with rectal intraepithelial neoplasia (RIN) and rectal carcinoma.
Genital HPVs may cause oral lesions or subclinical oral infection. Infection may result from oral sex or autoinoculation.
The virus can be transmitted from mother to infant during parturition and
may cause laryngeal papilloma in the infant or infection of the oral cavity.
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